福利导航站-福利导航做爱视频-福利电影91-福利电影av-福利电影国产衣社91-福利二区视频

最近搜索:細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
首頁>>免疫學(xué)>>一抗>>細(xì)胞分裂周期樣激酶2抗體
細(xì)胞分裂周期樣激酶2抗體
  • 產(chǎn)品貨號:
    BN41285R
  • 中文名稱:
    細(xì)胞分裂周期樣激酶2抗體
  • 英文名稱:
    Rabbit anti-CLK2 Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41285R-100ul

    100ul

    ¥2360.00

    交叉反應(yīng):Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

  • BN41285R-200ul

    200ul

    ¥3490.00

    交叉反應(yīng):Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken) 推薦應(yīng)用:WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱CLK2
中文名稱細(xì)胞分裂周期樣激酶2抗體
別    名CDC like kinase 2; CLK 2; CLK kinase; Clk2 Scamp3; Dual specificity protein kinase CLK2; hCLK 2; hCLK2; MGC61500; Tu52; CLK2_HUMAN.  
研究領(lǐng)域細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  細(xì)胞分化  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量60kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CLK2:401-499/499 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹CDC-like kinase 2 (CLK2) belongs to a family of autophosphorylating kinases termed CLK (CDC2/CDC28-like kinases), which have been shown to phosphorylate serine- and arginine-rich (SR) proteins of the spliceosomal complex, and to influence alternative splicing in overexpression systems. Recent findings demonstrated that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the CLK2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length.

Function:
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Subunit:
Interacts with RBMX. Interacts with AKT1 and UBL5.

Subcellular Location:
Isoform 1: Nucleus. Nucleus speckle. Isoform 2: Nucleus speckle.

Tissue Specificity:
Endothelial cells.

Post-translational modifications:
Autophosphorylates on all three types of residues. Phosphorylation on Ser-34 and Thr-127 by AKT1 is induced by ionizing radiation or insulin. Phosphorylation plays a critical role in cell proliferation following low dose radiation and prevents cell death following high dose radiation. Phosphorylation at Thr-344 by PKB/AKT2 induces its kinase activity which is required for its stability. The phosphorylation status at Ser-142 influences its subnuclear localization; inhbition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. Contains 1 protein kinase domain.

SWISS:
P49760

Gene ID:
1196

Database links:
UniProtKB/Swiss-Prot: P49760.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


主站蜘蛛池模板: 国产日韩亚洲不卡高清在线观看 | 国产精品一区欧美日韩制服 | 99视频精品在线 | 男女日b视频 | 丝袜美腿女邻居人 | h成年动漫在线 | 九九免费视频网站 | 日日摸夜夜摸人人看 | 欧美精品一区二区三区免费 | 4399高清在线观看 | 日本日本乱码伦视频免费 | 极品尤物一区二区 | 亚洲欧美精品一中文字幕 | 欧美日韩视频在线观看网址 | 九九九九热精品免费视频 | 91国语 | 欧美日韩中文字幕一区二区三区 | 热门短剧短视频 | 日本一区午 | 日韩综合第二区2区3一区 | 高清伦理 | 亚洲美女又黄又爽在线观看 | 欧美r级荡公乱妇在线观看 成人午夜影院网站 | 十九岁中国电影在线观看免费 | 成人日韩在线视频观看 | 欧美日韩精品网 | 国产suv精品一区二区五 | 免费午夜美女在线视频播放 | 日本五级床片午夜视频 | 玖玖玖国产福利在线观看 | 婷婷亚洲久悠悠色在线播放 | 亚洲91国产精品 | 天天色综合色 | 免费高清乱伦欧美 | 亚精区区一区区二在线观看 | 日产精品bd在线观看 | 亚洲阿v天堂在线2 | 92精品国产自产在线观看48 | 国产男女性潮高清免费网站 | 精品欧美日 | а∨天堂在线中 |